| Gene |
Nr4a1
|
| Protein Name |
NR4A1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Nuclear receptor subfamily 4 group A member 1 (Nuclear hormone receptor NUR/77) (Nuclear protein N10) (Orphan nuclear receptor HMR) |
| Protein Family |
Nuclear hormone receptor family |
| NCBI Gene ID |
15370
|
| UniProt ID |
P12813
|
| Enzyme Class |
- |
| Molecular Weight |
64738 |
| Protein Length |
601 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (PubMed:22427340). |
| Gene Ontology |
GO:0000977; GO:0000978; GO:0001077; GO:0001938; GO:0002042; GO:0003677; GO:0003707; GO:0004879; GO:0005634; GO:0005667; GO:0005829; GO:0006915; GO:0008134; GO:0008270; GO:0010035; GO:0031965; GO:0035259; GO:0035767; GO:0035914; GO:0035924; GO:0042803; GO:0043065; GO:0043154; GO:0043565; GO:0044344; GO:0045444; GO:0045786; GO:0045893; GO:0045944; GO:0046982; GO:0061469; GO:0071310; GO:0071376 |
