CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Pklr
Protein Name	KPYR_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	Pyruvate kinase PKLR (EC 2.7.1.40) (L-PK) (Pyruvate kinase isozymes L/R)
Protein Family	Pyruvate kinase family
NCBI Gene ID	24651
UniProt ID	P12928
Enzyme Class	2.7.1.40
Molecular Weight	62200
Protein Length	574
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + pyruvate = ADP + phosphoenolpyruvate.
Localization	N/A
Function (UniProt annotation)	Plays a key role in glycolysis.
Gene Ontology	GO:0000287; GO:0001666; GO:0004743; GO:0005524; GO:0005737; GO:0005829; GO:0005975; GO:0006096; GO:0006754; GO:0007584; GO:0009408; GO:0009749; GO:0010038; GO:0010226; GO:0016301; GO:0030955; GO:0032869; GO:0033198; GO:0042866; GO:0051591; GO:0071872

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK1 (Q14012)	Homo sapiens	T48	RASVAQLTQELGTAF	N/A	0.1611	-	-	-	-	-	-	In vitro
CAMK1 (Q14012)	Homo sapiens	T53	QLTQELGTAFFQQQQ	N/A	0.3053	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
rno00010	Glycolysis / Gluconeogenesis
rno00010	Glycolysis / Gluconeogenesis
rno00230	Purine metabolism
rno00230	Purine metabolism
rno00620	Pyruvate metabolism
rno00620	Pyruvate metabolism
rno01100	Metabolic pathways
rno01100	Metabolic pathways
rno04910	Insulin signaling pathway
rno04910	Insulin signaling pathway
rno04930	Type II diabetes mellitus
rno04930	Type II diabetes mellitus
rno04950	Maturity onset diabetes of the young
rno04950	Maturity onset diabetes of the young

No NCI Nature pathways found