| Gene |
XRCC6
|
| Protein Name |
XRCC6_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) |
| Protein Family |
Ku70 family |
| NCBI Gene ID |
2547
|
| UniProt ID |
P12956
|
| Enzyme Class |
3.6.4.-; 4.2.99.- |
| Molecular Weight |
69843 |
| Protein Length |
609 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Gene Ontology |
GO:0000723; GO:0000783; GO:0000784; GO:0002218; GO:0003677; GO:0003684; GO:0003690; GO:0003723; GO:0004003; GO:0005524; GO:0005576; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0005829; GO:0006266; GO:0006303; GO:0006310; GO:0007420; GO:0008022; GO:0016020; GO:0030332; GO:0032481; GO:0032991; GO:0032993; GO:0034774; GO:0042162; GO:0043312; GO:0043564; GO:0044212; GO:0044877; GO:0045087; GO:0045860; GO:0045892; GO:0045893; GO:0045944; GO:0048660; GO:0051290; GO:0051575; GO:0070419; GO:0071475; GO:0071480; GO:0071481; GO:0075713; GO:0097680; GO:1904813 |
