CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	CALD1
Protein Name	CALD1_CHICK
Organism	Gallus gallus (Chicken)
Alternative name(s)	Caldesmon (CDM)
Protein Family	Caldesmon family
NCBI Gene ID	373965
UniProt ID	P12957
Enzyme Class	-
Molecular Weight	88747
Protein Length	771
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm, cytoskeleton
Function (UniProt annotation)	Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.
Gene Ontology	GO:0003779; GO:0005516; GO:0005623; GO:0005856; GO:0006936; GO:0030016; GO:0044548; GO:0045159; GO:1903611

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MYLK (Q15746)	Homo sapiens	S658	KPAKPAASDLPVPAE	N/A	0.7672	TP	certain	experimental	73 \| 31 \|	20536391	-	In vitro
MYLK (Q15746)	Homo sapiens	S702	GLKVGVSSRINEWLT	N/A	0.5577	TP	certain	experimental	73 \| 31 \|	20536391	-	In vitro
MYLK (Q15746)	Homo sapiens	S73	SEVNAQNSVAEEETK	N/A	0.8198	TP	certain	experimental	73 \| 31 \|	20536391	-	In vitro
MYLK (Q15746)	Homo sapiens	T626	SGMKPAHTTAVVSKI	N/A	0.7629	TP	certain	experimental	73 \| 31 \|	20536391	-	In vitro
MYLK (Q15746)	Homo sapiens	T693	TGTPNKETAGLKVGV	N/A	0.8125	TP	certain	experimental	73 \| 31 \|	20536391	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S26	RLEAERLSYQRNDDD	N/A	0.6948	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S490	LTTPKLKSTENAFGR	N/A	0.7459	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S59	QKEEGDVSGEVTEKS	N/A	0.6948	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S602	CFSPKGSSLKIEERA	N/A	0.422	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S635	AVVSKIDSRLEQYTS	N/A	0.5176	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S73	SEVNAQNSVAEEETK	N/A	0.8198	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S741	RNLWEKQSVEKPAAS	N/A	0.7547	-	-	-	-	-	-	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	T484	QNGERELTTPKLKST	N/A	0.853	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
gga04270	Vascular smooth muscle contraction

No NCI Nature pathways found