| Gene |
Myog
|
| Protein Name |
MYOG_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Myogenin (MYOD1-related protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
17928
|
| UniProt ID |
P12979
|
| Enzyme Class |
- |
| Molecular Weight |
25203 |
| Protein Length |
224 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. |
| Function (UniProt annotation) |
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. |
| Gene Ontology |
GO:0000977; GO:0000978; GO:0000987; GO:0001077; GO:0001228; GO:0001503; GO:0003677; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0007049; GO:0007517; GO:0007519; GO:0008285; GO:0010831; GO:0014737; GO:0014842; GO:0014873; GO:0014878; GO:0014891; GO:0014894; GO:0014902; GO:0031490; GO:0032993; GO:0035914; GO:0042789; GO:0043565; GO:0045663; GO:0045820; GO:0045893; GO:0045944; GO:0046983; GO:0048741; GO:0048743; GO:0070888; GO:0071158; GO:0071285; GO:0071356; GO:0071363; GO:0071392; GO:1901739; GO:1901741; GO:1903862 |
