CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Hspb1
Protein Name	HSPB1_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Heat shock protein beta-1 (HspB1) (Growth-related 25 kDa protein) (Heat shock 25 kDa protein) (HSP 25) (Heat shock 27 kDa protein) (HSP 27) (p25)
Protein Family	Small heat shock protein (HSP20) family
NCBI Gene ID	15507
UniProt ID	P14602
Enzyme Class	-
Molecular Weight	23014
Protein Length	209
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).
Gene Ontology	GO:0000502; GO:0001932; GO:0005080; GO:0005622; GO:0005634; GO:0005737; GO:0005819; GO:0005886; GO:0006469; GO:0006986; GO:0008426; GO:0009615; GO:0010976; GO:0019901; GO:0030018; GO:0030424; GO:0030425; GO:0031430; GO:0031674; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0042803; GO:0043122; GO:0043130; GO:0043204; GO:0043292; GO:0043536; GO:0044183; GO:0045202; GO:0045766; GO:0061077; GO:0097512; GO:0098839; GO:0099641; GO:1902176; GO:1903202; GO:1904115; GO:2001028; GO:2001234

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S15	FSLLRSPSWEPFRDW	N/A	0.1137	TP	certain	experimental	72 \| 107 \|	1332886	-	In vivo
MAPKAPK2 (P49137)	Homo sapiens	S86	RALNRQLSSGVSEIR	N/A	0.3667	TP	certain	experimental	72 \| 107 \|	1332886	-	In vivo
CAMK1 (Q14012)	Homo sapiens	S15	FSLLRSPSWEPFRDW	N/A	0.1137	TP	likely	experimental	73 \| 214 \|	12538590	-	In vitro
CAMK4 (Q16566)	Homo sapiens	S15	FSLLRSPSWEPFRDW	N/A	0.1137	-	-	-	-	-	-	-
CAMK4 (Q16566)	Homo sapiens	S86	RALNRQLSSGVSEIR	N/A	0.3667	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
mmu04010	MAPK signaling pathway
mmu04370	VEGF signaling pathway
mmu05146	Amoebiasis

No NCI Nature pathways found