| Gene |
CACNA1C
|
| Protein Name |
CAC1C_RABIT |
| Organism |
Oryctolagus cuniculus (Rabbit) |
| Alternative name(s) |
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Smooth muscle calcium channel blocker receptor) (CACB-receptor) (Voltage-gated calcium channel subunit alpha Cav1.2) |
| Protein Family |
Calcium channel alpha-1 subunit (TC 1.A.1.11) family |
| NCBI Gene ID |
100101555
|
| UniProt ID |
P15381
|
| Enzyme Class |
- |
| Molecular Weight |
242784 |
| Protein Length |
2171 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:2474130, PubMed:2169433, PubMed:8232554, PubMed:9502794, PubMed:9278523, PubMed:15615847, PubMed:17525370, PubMed:21127204, PubMed:22928916, PubMed:23145875, PubMed:29363593, PubMed:22649239). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (PubMed:23145875). Plays an important role in excitation-contraction coupling in the heart (PubMed:17525370, PubMed:22928916, PubMed:23145875). Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (By similarity). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). |
| Gene Ontology |
GO:0005245; GO:0005516; GO:0005622; GO:0005886; GO:0005887; GO:0005891; GO:0007204; GO:0008331; GO:0010881; GO:0014069; GO:0016021; GO:0030054; GO:0030315; GO:0030425; GO:0042383; GO:0043204; GO:0045211; GO:0046872; GO:0060402; GO:0061337; GO:0061577; GO:0070588; GO:0098903; GO:1990454 |
