| Gene |
HIVEP1
|
| Protein Name |
ZEP1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) |
| Protein Family |
N/A |
| NCBI Gene ID |
3096
|
| UniProt ID |
P15822
|
| Enzyme Class |
- |
| Molecular Weight |
296865 |
| Protein Length |
2718 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Isoform 1: Nucleus.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm |
| Function (UniProt annotation) |
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| Gene Ontology |
GO:0000122; GO:0000980; GO:0000981; GO:0001206; GO:0003677; GO:0005634; GO:0005654; GO:0005739; GO:0016604; GO:0046872 |
