| Gene |
CD44
|
| Protein Name |
CD44_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) |
| Protein Family |
N/A |
| NCBI Gene ID |
960
|
| UniProt ID |
P16070
|
| Enzyme Class |
- |
| Molecular Weight |
81538 |
| Protein Length |
742 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). |
| Gene Ontology |
GO:0004888; GO:0005518; GO:0005540; GO:0005794; GO:0005829; GO:0005886; GO:0005887; GO:0005902; GO:0005925; GO:0006954; GO:0007155; GO:0007160; GO:0009986; GO:0016323; GO:0016324; GO:0022617; GO:0030198; GO:0030214; GO:0030667; GO:0031258; GO:0033138; GO:0034116; GO:0035692; GO:0042995; GO:0043066; GO:0043154; GO:0043312; GO:0043518; GO:0044319; GO:0044344; GO:0050731; GO:0050900; GO:0051216; GO:0060333; GO:0070062; GO:0070374; GO:0070487; GO:0098609; GO:1900625; GO:1902166; GO:2000392 |
