| Gene |
ITGB4
|
| Protein Name |
ITB4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Integrin beta-4 (GP150) (CD antigen CD104) |
| Protein Family |
Integrin beta chain family |
| NCBI Gene ID |
3691
|
| UniProt ID |
P16144
|
| Enzyme Class |
- |
| Molecular Weight |
202167 |
| Protein Length |
1822 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. |
| Function (UniProt annotation) |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). |
| Gene Ontology |
GO:0001664; GO:0005178; GO:0005886; GO:0005925; GO:0006914; GO:0007155; GO:0007160; GO:0007229; GO:0008305; GO:0009611; GO:0009986; GO:0016477; GO:0030054; GO:0030056; GO:0030198; GO:0031252; GO:0031581; GO:0033627; GO:0035878; GO:0043235; GO:0043588; GO:0048333; GO:0048565; GO:0048870; GO:0070062; GO:0072001; GO:0097186 |
