| Gene |
OSBP
|
| Protein Name |
OSBP1_RABIT |
| Organism |
Oryctolagus cuniculus (Rabbit) |
| Alternative name(s) |
Oxysterol-binding protein 1 |
| Protein Family |
OSBP family |
| NCBI Gene ID |
100009048
|
| UniProt ID |
P16258
|
| Enzyme Class |
- |
| Molecular Weight |
89478 |
| Protein Length |
809 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytosol |
| Function (UniProt annotation) |
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:18165705). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (By similarity). Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity). |
| Gene Ontology |
GO:0000139; GO:0005789; GO:0005802; GO:0005829; GO:0015248; GO:0015485; GO:0015918; GO:0032367; GO:0048471; GO:0070273 |
