CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	HIST1H1C
Protein Name	H12_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)
Protein Family	Histone H1/H5 family
NCBI Gene ID	3006
UniProt ID	P16403
Enzyme Class	-
Molecular Weight	21365
Protein Length	213
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
Function (UniProt annotation)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Gene Ontology	GO:0000122; GO:0000786; GO:0003690; GO:0003723; GO:0005634; GO:0005719; GO:0006334; GO:0006355; GO:0016584; GO:0030261; GO:0031490; GO:0031492; GO:0031936; GO:0035327; GO:0045910; GO:0080182; GO:0098532

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK2 (O96017)	Homo sapiens	S36	GGTPRKASGPPVSEL	0.768	0.7505	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S55	VAASKERSGVSLAAL	0.198	0.5382	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S89	LGLKSLVSKGTLVQT	0.092	0.5098	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	T167	KPAAATVTKKVAKSP	0.099	0.7718	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	T92	KSLVSKGTLVQTKGT	0.371	0.5211	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found