| Gene |
GABRB1
|
| Protein Name |
GBRB1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) |
| Protein Family |
Ligand-gated ion channel (TC 1.A.9) family |
| NCBI Gene ID |
2560
|
| UniProt ID |
P18505
|
| Enzyme Class |
- |
| Molecular Weight |
54235 |
| Protein Length |
474 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell junction, synapse, postsynaptic cell membrane |
| Function (UniProt annotation) |
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. |
| Gene Ontology |
GO:0004890; GO:0005635; GO:0005737; GO:0005886; GO:0005887; GO:0006811; GO:0007165; GO:0007214; GO:0007268; GO:0009636; GO:0015276; GO:0021954; GO:0022851; GO:0030054; GO:0030425; GO:0032570; GO:0034220; GO:0034707; GO:0042391; GO:0042698; GO:0043005; GO:0045202; GO:0045211; GO:0050811; GO:0050877; GO:0071420; GO:0098982; GO:1902476; GO:1902711; GO:1904315 |
