| Gene |
LIG1
|
| Protein Name |
DNLI1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) |
| Protein Family |
ATP-dependent DNA ligase family |
| NCBI Gene ID |
3978
|
| UniProt ID |
P18858
|
| Enzyme Class |
6.5.1.1 |
| Molecular Weight |
101736 |
| Protein Length |
919 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate. |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. |
| Gene Ontology |
GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0006266; GO:0006273; GO:0006281; GO:0006283; GO:0006284; GO:0006297; GO:0006298; GO:0006310; GO:0009653; GO:0043231; GO:0046872; GO:0051103; GO:0051301; GO:0071897; GO:1903461 |
