| Gene |
Gria1
|
| Protein Name |
GRIA1_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1) |
| Protein Family |
Glutamate-gated ion channel (TC 1.A.10.1) family |
| NCBI Gene ID |
50592
|
| UniProt ID |
P19490
|
| Enzyme Class |
- |
| Molecular Weight |
101579 |
| Protein Length |
907 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Gene Ontology |
GO:0001540; GO:0001919; GO:0001965; GO:0004970; GO:0004971; GO:0005769; GO:0005789; GO:0005829; GO:0005886; GO:0007616; GO:0008022; GO:0008179; GO:0008328; GO:0009636; GO:0009986; GO:0010226; GO:0014069; GO:0014070; GO:0019228; GO:0019901; GO:0019904; GO:0021510; GO:0030054; GO:0030165; GO:0030425; GO:0031267; GO:0031489; GO:0031594; GO:0031623; GO:0031681; GO:0031698; GO:0031901; GO:0032279; GO:0032281; GO:0032355; GO:0032991; GO:0035249; GO:0042220; GO:0042493; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0043198; GO:0043434; GO:0044309; GO:0045202; GO:0045838; GO:0046685; GO:0048167; GO:0050804; GO:0050806; GO:0051018; GO:0051602; GO:0055038; GO:0060076; GO:0060992; GO:0071230; GO:0071359; GO:0071363; GO:0071375; GO:0071407; GO:0071418; GO:0097060; GO:0097110; GO:0098978; GO:0099055; GO:0099056; GO:0099061; GO:0099583 |
