| Gene |
Gria4
|
| Protein Name |
GRIA4_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) |
| Protein Family |
Glutamate-gated ion channel (TC 1.A.10.1) family |
| NCBI Gene ID |
29629
|
| UniProt ID |
P19493
|
| Enzyme Class |
- |
| Molecular Weight |
100758 |
| Protein Length |
902 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. |
| Function (UniProt annotation) |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). |
| Gene Ontology |
GO:0004970; GO:0004971; GO:0005886; GO:0007268; GO:0008328; GO:0014069; GO:0030054; GO:0030425; GO:0032281; GO:0032983; GO:0042802; GO:0043025; GO:0043195; GO:0043197; GO:0045202; GO:0050803; GO:0050804; GO:0051968; GO:0060992; GO:0098978; GO:0099061 |
