| Gene |
CDK11B
|
| Protein Name |
CD11B_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
984
|
| UniProt ID |
P21127
|
| Enzyme Class |
2.7.11.22 |
| Molecular Weight |
92620 |
| Protein Length |
795 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm. Nucleus. |
| Function (UniProt annotation) |
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Gene Ontology |
GO:0000278; GO:0001558; GO:0003723; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0006355; GO:0006468; GO:0006915; GO:0008283; GO:0050684 |
