| Gene |
OSBP
|
| Protein Name |
OSBP1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Oxysterol-binding protein 1 |
| Protein Family |
OSBP family |
| NCBI Gene ID |
5007
|
| UniProt ID |
P22059
|
| Enzyme Class |
- |
| Molecular Weight |
89421 |
| Protein Length |
807 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytosol |
| Function (UniProt annotation) |
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). |
| Gene Ontology |
GO:0000139; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005794; GO:0005802; GO:0005829; GO:0005886; GO:0006699; GO:0008142; GO:0008289; GO:0015248; GO:0015918; GO:0016020; GO:0019904; GO:0030054; GO:0032367; GO:0032934; GO:0043231; GO:0044128; GO:0048471; GO:0070273; GO:0097038 |
