CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Gabrg2
Protein Name	GBRG2_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2)
Protein Family	Ligand-gated ion channel (TC 1.A.9) family
NCBI Gene ID	14406
UniProt ID	P22723
Enzyme Class	-
Molecular Weight	55099
Protein Length	474
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell junction, synapse, postsynaptic cell membrane
Function (UniProt annotation)	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Gene Ontology	GO:0004890; GO:0005237; GO:0005254; GO:0005737; GO:0005887; GO:0007165; GO:0007214; GO:0007268; GO:0009791; GO:0022851; GO:0030054; GO:0030424; GO:0030534; GO:0030659; GO:0032590; GO:0034220; GO:0034707; GO:0042391; GO:0043005; GO:0045202; GO:0050877; GO:0051932; GO:0060077; GO:0060078; GO:0071420; GO:0098794; GO:0098978; GO:0098982; GO:0099060; GO:1902476; GO:1902710; GO:1902711; GO:1904315

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S381	NPLLRMFSFKAPTID	N/A	0.0948	-	-	-	-	8027073	Non high throughput (8027073)	-
CAMK2A (Q9UQM7)	Homo sapiens	S393	TIDIRPRSATIQMNN	N/A	0.3494	-	-	-	-	8027073	Non high throughput (8027073)	-
CAMK2A (Q9UQM7)	Homo sapiens	T395	DIRPRSATIQMNNAT	N/A	0.3087	-	-	-	-	8027073	Non high throughput (8027073)	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
mmu04080	Neuroactive ligand-receptor interaction

No NCI Nature pathways found