| Gene |
BDNF
|
| Protein Name |
BDNF_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Brain-derived neurotrophic factor (BDNF) (Abrineurin) |
| Protein Family |
NGF-beta family |
| NCBI Gene ID |
627
|
| UniProt ID |
P23560
|
| Enzyme Class |
- |
| Molecular Weight |
27818 |
| Protein Length |
247 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Secreted. |
| Function (UniProt annotation) |
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. |
| Gene Ontology |
GO:0005576; GO:0005615; GO:0005737; GO:0005739; GO:0007169; GO:0007202; GO:0007399; GO:0007411; GO:0007416; GO:0007422; GO:0007613; GO:0008021; GO:0008083; GO:0010832; GO:0016607; GO:0021675; GO:0030424; GO:0030425; GO:0031410; GO:0031547; GO:0031550; GO:0038180; GO:0043524; GO:0045664; GO:0048011; GO:0048471; GO:0048668; GO:0048672; GO:0048812; GO:0050804; GO:0051965; GO:1900122; GO:1903997; GO:2000008 |
