| Gene |
MCM3
|
| Protein Name |
MCM3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) |
| Protein Family |
MCM family |
| NCBI Gene ID |
4172
|
| UniProt ID |
P25205
|
| Enzyme Class |
3.6.4.12 |
| Molecular Weight |
90981 |
| Protein Length |
808 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + H(2)O = ADP + phosphate. |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. |
| Gene Ontology |
GO:0000082; GO:0000784; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005658; GO:0005813; GO:0006260; GO:0006270; GO:0016020; GO:0042555; GO:0048471 |
