| Gene |
DUSP1
|
| Protein Name |
DUS1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) |
| Protein Family |
Protein-tyrosine phosphatase family |
| NCBI Gene ID |
1843
|
| UniProt ID |
P28562
|
| Enzyme Class |
3.1.3.16; 3.1.3.48 |
| Molecular Weight |
39298 |
| Protein Length |
367 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Gene Ontology |
GO:0000188; GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0007162; GO:0008138; GO:0008285; GO:0008330; GO:0009416; GO:0017017; GO:0019838; GO:0032355; GO:0032526; GO:0032870; GO:0033574; GO:0035335; GO:0035556; GO:0035970; GO:0042542; GO:0043065; GO:0043066; GO:0043407; GO:0043409; GO:0051019; GO:0051384; GO:0051447; GO:0051591; GO:0051592; GO:0070262; GO:0070373; GO:0071850; GO:0090027; GO:0090266; GO:1903753; GO:1990869; GO:2000279 |
