| Gene |
CDC27
|
| Protein Name |
CDC27_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) |
| Protein Family |
APC3/CDC27 family |
| NCBI Gene ID |
996
|
| UniProt ID |
P30260
|
| Enzyme Class |
- |
| Molecular Weight |
91867 |
| Protein Length |
824 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. |
| Gene Ontology |
GO:0005634; GO:0005654; GO:0005680; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007091; GO:0008283; GO:0019903; GO:0031145; GO:0070979 |
