| Gene |
WEE1
|
| Protein Name |
WEE1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
7465
|
| UniProt ID |
P30291
|
| Enzyme Class |
2.7.10.2 |
| Molecular Weight |
71597 |
| Protein Length |
646 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. |
| Gene Ontology |
GO:0000086; GO:0000226; GO:0000287; GO:0004672; GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007093; GO:0016301; GO:0030010; GO:0048812; GO:0051301; GO:2000134 |
