CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

BRSK2

Synonyms

C11orf7 PEN11B SADA STK29

Protein Name

Serine/threonine-protein kinase BRSK2

UniProt ID

Q8IWQ3

Ensembl Gene ID

9606.ENSP00000310697

NCBI Gene ID

9024

Molecular Weight

81,633

Protein Length

736

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; 2.7.11.26 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.; ATP + [tau protein] = ADP + [tau protein] phosphate.

Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin.

Function

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

Gene Ontology

GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007409; GO:0010975; GO:0018105; GO:0019901; GO:0030010; GO:0030182; GO:0031532; GO:0035556; GO:0036503; GO:0043462; GO:0048471; GO:0050321; GO:0050770; GO:0051117; GO:0051301; GO:0060590; GO:0061178; GO:0070059; GO:0090176; GO:0150034; GO:1904152; GO:2000807

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CDK16 (Q00536)	Homo sapiens	S12	KKIKRQLSMTLRGGR	0.998	0.725	TP	certain	experimental	66 \| 40 \| 23 \| 72 \| 9 \|	22798068	-	-
PAK1 (Q13153)	Homo sapiens	T423	PEQSKRSTMVGTPYW	0.735	0.422	TP	certain	experimental	23 \| 72 \| 73 \| 36 \|	22669945	-	-
PRKAA1 (Q13131)	Homo sapiens	T183	SDGEFLRTSCGSPNY	0.698	0.2951	-	-	-	-	-	-	In vitro
TSC2 (P49815)	Homo sapiens	S1387	QPLSKSSSSPELQTL	0.645	0.853	-	-	-	-	-	-	in-vitro
MAPT (P10636)	Homo sapiens	S579	NVKSKIGSTENLKHQ	0.79	0.8198	-	-	-	-	-	-	-
WEE1 (P30291)	Homo sapiens	S642	KKMNRSVSLTIY___	0.904	0.1823	-	-	-	-	-	-	-
N/A (B4DX61)	Homo sapiens	S233	SGLYRSPSMPENLNR	-	0.6227	-	-	-	-	-	-	-
MAPT (P10636)	Homo sapiens	T529	TPGSRSRTPSLPTPP	0.375	0.9744	-	-	-	-	-	-	-
BRSK2 (Q8IWQ3)	Homo sapiens	T174	VGDSLLETSCGSPHY	0.628	0.1731	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found