| Gene |
SLC6A4
|
| Protein Name |
SC6A4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) |
| Protein Family |
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family |
| NCBI Gene ID |
6532
|
| UniProt ID |
P31645
|
| Enzyme Class |
- |
| Molecular Weight |
70325 |
| Protein Length |
630 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. |
| Gene Ontology |
GO:0001666; GO:0005335; GO:0005829; GO:0005886; GO:0005887; GO:0006837; GO:0007584; GO:0007613; GO:0007623; GO:0008504; GO:0009636; GO:0010008; GO:0010628; GO:0012505; GO:0014064; GO:0015844; GO:0017022; GO:0017075; GO:0017137; GO:0019811; GO:0021941; GO:0032227; GO:0032355; GO:0035176; GO:0042136; GO:0042310; GO:0042493; GO:0042713; GO:0042803; GO:0043005; GO:0045121; GO:0045665; GO:0045787; GO:0046621; GO:0046872; GO:0048854; GO:0050998; GO:0051015; GO:0051259; GO:0051260; GO:0051378; GO:0051610; GO:0071300; GO:0071321; GO:0090067; GO:0099055; GO:0099056; GO:0099154 |
