| Gene |
TTK
|
| Protein Name |
TTK_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
7272
|
| UniProt ID |
P33981
|
| Enzyme Class |
2.7.12.1 |
| Molecular Weight |
97072 |
| Protein Length |
857 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
N/A |
| Function (UniProt annotation) |
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. |
| Gene Ontology |
GO:0000776; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005819; GO:0007051; GO:0007052; GO:0007094; GO:0008284; GO:0010862; GO:0016020; GO:0016321; GO:0018105; GO:0018107; GO:0033316; GO:0034501; GO:0042803; GO:0043515; GO:0046777; GO:0051304; GO:1903096 |
