CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	SPR
Protein Name	SPRE_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Sepiapterin reductase (SPR) (EC 1.1.1.153)
Protein Family	Sepiapterin reductase family
NCBI Gene ID	6697
UniProt ID	P35270
Enzyme Class	1.1.1.153
Molecular Weight	28048
Protein Length	261
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	L-erythro-7
Localization	Cytoplasm.
Function (UniProt annotation)	Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Gene Ontology	GO:0004033; GO:0004757; GO:0005654; GO:0005829; GO:0006729; GO:0006809; GO:0050661; GO:0050999; GO:0051186; GO:0055114; GO:0070062

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S213	QQLARETSVDPDMRK	0.339	0.5342	-	-	-	-	-	-	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa00790	Folate biosynthesis
hsa01100	Metabolic pathways

No NCI Nature pathways found