CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	HRH1
Protein Name	HRH1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histamine H1 receptor (H1R) (HH1R)
Protein Family	G-protein coupled receptor 1 family
NCBI Gene ID	3269
UniProt ID	P35367
Enzyme Class	-
Molecular Weight	55784
Protein Length	487
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Ontology	GO:0004930; GO:0004969; GO:0004993; GO:0005829; GO:0005886; GO:0005887; GO:0006954; GO:0007186; GO:0007187; GO:0007200; GO:0007268; GO:0007613; GO:0008542; GO:0030425; GO:0030594; GO:0032962; GO:0043114; GO:0045907; GO:0048016; GO:0048167; GO:0048245; GO:0071420

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S396	FTWKRLRSHSRQYVS	0.321	0.0749	-	-	-	-	15107581	Non high throughput (15107581)	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	S398	WKRLRSHSRQYVSGL	0.94	0.1702	-	-	-	-	15107581	Non high throughput (15107581)	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	T140	LRYLKYRTKTRASAT	0.825	0.0646	-	-	-	-	15107581	Non high throughput (15107581)	In vitro
CAMK2A (Q9UQM7)	Homo sapiens	T142	YLKYRTKTRASATIL	0.164	0.0231	-	-	-	-	15107581	Non high throughput (15107581)	In vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

No NCI Nature pathways found