| Gene |
ADRA1B
|
| Protein Name |
ADA1B_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) |
| Protein Family |
G-protein coupled receptor 1 family |
| NCBI Gene ID |
147
|
| UniProt ID |
P35368
|
| Enzyme Class |
- |
| Molecular Weight |
56836 |
| Protein Length |
520 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus membrane; Multi-pass membrane protein. Cell membrane Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. |
| Function (UniProt annotation) |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. |
| Gene Ontology |
GO:0001994; GO:0004935; GO:0004937; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0005901; GO:0007186; GO:0007188; GO:0007200; GO:0007204; GO:0007267; GO:0007275; GO:0008283; GO:0031965; GO:0035556; GO:0042593; GO:0043410; GO:0045907; GO:0045987; GO:0046982; GO:0055117; GO:0071880 |
