| Gene |
DRD3
|
| Protein Name |
DRD3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
D(3) dopamine receptor (Dopamine D3 receptor) |
| Protein Family |
G-protein coupled receptor 1 family |
| NCBI Gene ID |
1814
|
| UniProt ID |
P35462
|
| Enzyme Class |
- |
| Molecular Weight |
44225 |
| Protein Length |
400 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. |
| Function (UniProt annotation) |
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. |
| Gene Ontology |
GO:0000122; GO:0001591; GO:0001963; GO:0001975; GO:0002016; GO:0002031; GO:0004935; GO:0005886; GO:0005887; GO:0006874; GO:0006914; GO:0007186; GO:0007188; GO:0007191; GO:0007195; GO:0007611; GO:0007612; GO:0007626; GO:0008144; GO:0008284; GO:0008542; GO:0014059; GO:0019216; GO:0019904; GO:0030139; GO:0031748; GO:0032416; GO:0032467; GO:0032922; GO:0034776; GO:0035176; GO:0035240; GO:0035483; GO:0035815; GO:0040014; GO:0042220; GO:0042417; GO:0042493; GO:0042995; GO:0043066; GO:0043278; GO:0045177; GO:0045187; GO:0045776; GO:0045840; GO:0045944; GO:0046717; GO:0048148; GO:0048715; GO:0050482; GO:0050709; GO:0050883; GO:0051584; GO:0051898; GO:0060134; GO:0060160; GO:0060161; GO:0071880; GO:0090325; GO:0098691; GO:0098978; GO:0098982; GO:0099061; GO:0099149 |
