| Gene |
MAP2K2
|
| Protein Name |
MP2K2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
5605
|
| UniProt ID |
P36507
|
| Enzyme Class |
2.7.12.2 |
| Molecular Weight |
44424 |
| Protein Length |
400 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). |
| Gene Ontology |
GO:0000165; GO:0000187; GO:0004674; GO:0004708; GO:0004712; GO:0004713; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005769; GO:0005770; GO:0005778; GO:0005783; GO:0005794; GO:0005829; GO:0005874; GO:0005911; GO:0005925; GO:0009898; GO:0010629; GO:0023014; GO:0030165; GO:0031098; GO:0032147; GO:0032872; GO:0036289; GO:0043539; GO:0045893; GO:0046872; GO:0048471; GO:0070371; GO:0071902; GO:0090170; GO:0097110; GO:1903800; GO:2000641 |
