| Gene |
Cdkn1a
|
| Protein Name |
CDN1A_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein) (p21) |
| Protein Family |
CDI family |
| NCBI Gene ID |
12575
|
| UniProt ID |
P39689
|
| Enzyme Class |
- |
| Molecular Weight |
17785 |
| Protein Length |
159 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). |
| Gene Ontology |
GO:0000079; GO:0000082; GO:0000086; GO:0000307; GO:0004693; GO:0004860; GO:0004861; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006974; GO:0006977; GO:0006978; GO:0007050; GO:0007346; GO:0008285; GO:0009411; GO:0010629; GO:0010942; GO:0016604; GO:0019901; GO:0019912; GO:0030308; GO:0030332; GO:0030890; GO:0031625; GO:0031668; GO:0032991; GO:0033158; GO:0034198; GO:0042326; GO:0042771; GO:0043066; GO:0043068; GO:0044877; GO:0045736; GO:0045860; GO:0046872; GO:0048146; GO:0048471; GO:0051726; GO:0070557; GO:0071479; GO:0071480; GO:0071493; GO:0071850; GO:0090398; GO:1904030; GO:1904706; GO:2000134; GO:2000278; GO:2000379 |
