| Gene |
FEN1
|
| Protein Name |
FEN1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) |
| Protein Family |
XPG/RAD2 endonuclease family |
| NCBI Gene ID |
2237
|
| UniProt ID |
P39748
|
| Enzyme Class |
3.1.-.- |
| Molecular Weight |
42593 |
| Protein Length |
380 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; Isoform FENMIT: Mitochondrion |
| Function (UniProt annotation) |
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
| Gene Ontology |
GO:0000287; GO:0000724; GO:0000784; GO:0003677; GO:0003684; GO:0003690; GO:0004519; GO:0004523; GO:0004527; GO:0005634; GO:0005654; GO:0005730; GO:0005739; GO:0006260; GO:0006281; GO:0006284; GO:0006302; GO:0006309; GO:0007613; GO:0008309; GO:0008409; GO:0009650; GO:0016020; GO:0017108; GO:0030145; GO:0032201; GO:0032991; GO:0043137; GO:0045145; GO:0045876; GO:0048256; GO:0051908; GO:0090305 |
