| Gene |
RPL13A
|
| Protein Name |
RL13A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13) |
| Protein Family |
Universal ribosomal protein uL13 family |
| NCBI Gene ID |
23521
|
| UniProt ID |
P40429
|
| Enzyme Class |
- |
| Molecular Weight |
23577 |
| Protein Length |
203 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. |
| Gene Ontology |
GO:0000184; GO:0003723; GO:0003729; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0006413; GO:0006614; GO:0015934; GO:0016020; GO:0017148; GO:0022625; GO:0071346; GO:0097452; GO:1901194; GO:1990904 |
