| Gene |
ID1
|
| Protein Name |
ID1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1) |
| Protein Family |
N/A |
| NCBI Gene ID |
3397
|
| UniProt ID |
P41134
|
| Enzyme Class |
- |
| Molecular Weight |
16133 |
| Protein Length |
155 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm Nucleus. |
| Function (UniProt annotation) |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). |
| Gene Ontology |
GO:0000122; GO:0000981; GO:0001085; GO:0001525; GO:0001886; GO:0003700; GO:0005634; GO:0005654; GO:0005794; GO:0005813; GO:0006351; GO:0007179; GO:0007420; GO:0007507; GO:0007623; GO:0008022; GO:0008134; GO:0010621; GO:0010628; GO:0030182; GO:0030509; GO:0031648; GO:0032233; GO:0032963; GO:0036164; GO:0042803; GO:0043066; GO:0043392; GO:0043408; GO:0043433; GO:0043534; GO:0043621; GO:0045602; GO:0045665; GO:0045668; GO:0045765; GO:0045892; GO:0046677; GO:0047485; GO:0048514; GO:0050679; GO:0050774; GO:0051726; GO:0060425; GO:0060426; GO:0070628; GO:0071364; GO:0090074; GO:0120163; GO:1901653; GO:1903351; GO:1990090 |
