| Gene |
SLC1A3
|
| Protein Name |
EAA1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) |
| Protein Family |
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
| NCBI Gene ID |
6507
|
| UniProt ID |
P43003
|
| Enzyme Class |
- |
| Molecular Weight |
59572 |
| Protein Length |
542 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). |
| Gene Ontology |
GO:0001504; GO:0005313; GO:0005314; GO:0005886; GO:0005887; GO:0006537; GO:0006811; GO:0007268; GO:0007605; GO:0009416; GO:0009449; GO:0009611; GO:0009986; GO:0014047; GO:0015171; GO:0015501; GO:0015813; GO:0016020; GO:0016595; GO:0021545; GO:0031223; GO:0043005; GO:0043025; GO:0046677; GO:0046872; GO:0048667; GO:0050806; GO:0050885; GO:0051938; GO:0070779; GO:0071805; GO:0098712; GO:0140009; GO:1902476 |
