CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	MATR3
Protein Name	MATR3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Matrin-3
Protein Family	N/A
NCBI Gene ID	9782
UniProt ID	P43243
Enzyme Class	-
Molecular Weight	94623
Protein Length	847
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus matrix.
Function (UniProt annotation)	May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233).
Gene Ontology	GO:0002218; GO:0003723; GO:0005198; GO:0005637; GO:0008270; GO:0010608; GO:0016020; GO:0016363; GO:0035198; GO:0042802; GO:0045087

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S195	SFDDRGPSLNPVLDY	0.478	0.6227	-	-	-	-	-	-	in-vitro
CHEK1 (O14757)	Homo sapiens	S4	____MSKSFQQSSLS	0.775	0.6375	-	-	-	-	-	-	in-vitro
CHEK1 (O14757)	Homo sapiens	T150	LQLKRRRTEEGPTLS	0.002	0.5419	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found