| Gene |
MKI67
|
| Protein Name |
KI67_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) |
| Protein Family |
N/A |
| NCBI Gene ID |
4288
|
| UniProt ID |
P46013
|
| Enzyme Class |
- |
| Molecular Weight |
358694 |
| Protein Length |
3256 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Chromosome |
| Function (UniProt annotation) |
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). |
| Gene Ontology |
GO:0003677; GO:0003723; GO:0005524; GO:0005634; GO:0005694; GO:0005730; GO:0007049; GO:0007088; GO:0008022; GO:0008283; GO:0016020; GO:0016604; GO:0051983; GO:1902275 |
