| Gene |
Cdkn1b
|
| Protein Name |
CDN1B_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) |
| Protein Family |
CDI family |
| NCBI Gene ID |
12576
|
| UniProt ID |
P46414
|
| Enzyme Class |
- |
| Molecular Weight |
22193 |
| Protein Length |
197 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Cytoplasm. Endosome |
| Function (UniProt annotation) |
Important regulator of cell cycle progression (PubMed:8033213, PubMed:12972555). Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes (PubMed:8033213). Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. |
| Gene Ontology |
GO:0000082; GO:0001666; GO:0001890; GO:0004693; GO:0004860; GO:0004861; GO:0005634; GO:0005737; GO:0005768; GO:0005829; GO:0006813; GO:0007050; GO:0007096; GO:0007219; GO:0007605; GO:0008219; GO:0008284; GO:0008285; GO:0009749; GO:0010942; GO:0019901; GO:0019903; GO:0030308; GO:0030332; GO:0030544; GO:0031116; GO:0031464; GO:0032355; GO:0032991; GO:0033673; GO:0042326; GO:0042493; GO:0043066; GO:0043200; GO:0043231; GO:0043434; GO:0044877; GO:0045732; GO:0045736; GO:0045737; GO:0045786; GO:0045892; GO:0045930; GO:0046686; GO:0048102; GO:0048839; GO:0050680; GO:0051087; GO:0051271; GO:0060770; GO:0071236; GO:0071285; GO:0071407; GO:0071850; GO:1902746; GO:1904030; GO:1904706 |
