| Gene |
Pla2g4a
|
| Protein Name |
PA24A_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] |
| Protein Family |
N/A |
| NCBI Gene ID |
18783
|
| UniProt ID |
P47713
|
| Enzyme Class |
3.1.1.4; 3.1.1.5 |
| Molecular Weight |
85222 |
| Protein Length |
748 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.; 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. |
| Localization |
Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. |
| Function (UniProt annotation) |
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. |
| Gene Ontology |
GO:0001542; GO:0004622; GO:0004623; GO:0005509; GO:0005544; GO:0005634; GO:0005737; GO:0005783; GO:0005794; GO:0005811; GO:0005829; GO:0008284; GO:0010033; GO:0019369; GO:0031340; GO:0031394; GO:0035035; GO:0042127; GO:0042588; GO:0043065; GO:0043129; GO:0043231; GO:0046456; GO:0046475; GO:0046697; GO:0047498; GO:0048471; GO:0050482; GO:0050729; GO:0051592; GO:0071236; GO:0102567; GO:0102568 |
