CaMKipedia | Result

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Sequence Viewer

Gene

MKNK1

Synonyms

MNK1

Protein Name

MAP kinase-interacting serine/threonine-protein kinase 1

UniProt ID

Q9BUB5

Ensembl Gene ID

9606.ENSP00000361014

NCBI Gene ID

8569

Molecular Weight

51,342

Protein Length

465

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2hw6)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm. Nucleus.

Function

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Gene Ontology

GO:0004674; GO:0004683; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006417; GO:0006468; GO:0009931; GO:0018105; GO:0035556; GO:0046872

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Eif4e (P63073)	Mus musculus	S209	DTATKSGSTTKNRFV	-	0.4541	TP	certain	experimental	72 \| 73 \| 9 \| 74 \|	9878069	-	In vitro and in vivo
Eif4e (P63073)	Mus musculus	T210	TATKSGSTTKNRFVV	-	0.4409	TP	certain	experimental	72 \| 73 \| 9 \| 74 \|	9878069	-	In vitro and in vivo
SPRY2 (O43597)	Homo sapiens	S112	APLSRSISTVSSGSR	0.354	0.712	TP	certain	experimental	107 \| 147 \| 73 \| 72 \| 62 \| 148 \|	16479008	-	-
SPRY2 (O43597)	Homo sapiens	S121	VSSGSRSSTRTSTSS	0.854	0.7369	TP	certain	experimental	107 \| 147 \| 73 \| 72 \| 62 \| 148 \|	16479008	-	-
SFPQ (P23246)	Homo sapiens	S8	MSRDRFRSRGGGGGG	0.448	0.9916	TP	certain	experimental	72 \| 107 \| 30 \| 9 \| 55 \| 148 \|	17965020	-	-
SFPQ (P23246)	Homo sapiens	S283	EGFKANLSLLRRPGE	0.784	0.6851	TP	certain	experimental	72 \| 107 \| 30 \| 9 \| 148 \|	17965020	-	-
HNRNPA1 * (P09651)	Homo sapiens	S192	EMASASSSQRGRSGS	0.141	0.7331	TP	certain	experimental	72 \| 135 \| 148 \| 73 \| 107 \| 9 \|	16111636	-	-
HNRNPA1 * (P09651)	Homo sapiens	S362	GGYGGSSSSSSYGSG	0.119	0.6375	TP	certain	experimental	72 \| 30 \| 9 \| 148 \| 73 \| 107 \|	16111636	-	-
HNRNPA1 * (P09651)	Homo sapiens	S363	GYGGSSSSSSYGSGR	0.046	0.6043	TP	certain	experimental	72 \| 30 \| 9 \| 148 \| 73 \| 107 \|	16111636	-	-
HNRNPA1 * (P09651)	Homo sapiens	S364	YGGSSSSSSYGSGRR	0.06	0.5854	TP	certain	experimental	72 \| 30 \| 9 \| 148 \| 73 \| 107 \|	16111636	-	-
EIF4E * (P06730)	Homo sapiens	S209	DTATKSGSTTKNRFV	0.815	0.4582	TP	certain	experimental	72 \| 137 \| 133 \| 147 \| 73 \|	11154262	-	-
Pla2g4a (P47713)	Mus musculus	S726	RQNPSRCSVSLSNVE	-	0.4017	-	-	-	-	10978317	Non high throughput (10978317)	-
PNPLA8 (Q9NP80)	Homo sapiens	S511	ELYRKLGSDVFSQNV	0.214	0.0734	-	-	-	-	-	-	in-vivo
PLA2G4A (P47712)	Homo sapiens	S727	RQNPSRCSVSLSNVE	0.781	0.4409	-	-	-	-	-	-	-
N/A (A8K2S1)	Homo sapiens	S727	RQNPSRCSVSLSNVE	-	0.4409	-	-	-	-	-	-	-
EIF4E (Q32Q75)	Homo sapiens	S209	DTATKSGSTTKNRFV	-	0.4582	-	-	-	-	-	-	-
EIF4E (Q32Q75)	Homo sapiens	T210	TATKSGSTTKNRFVV	-	0.4476	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04910	Insulin signaling pathway

NCI Nature PID Pathways

Pathway ID	Pathway Name
mtor_4pathway	mTOR signaling pathway
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta