| Gene |
GRIA4
|
| Protein Name |
GRIA4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) |
| Protein Family |
Glutamate-gated ion channel (TC 1.A.10.1) family |
| NCBI Gene ID |
2893
|
| UniProt ID |
P48058
|
| Enzyme Class |
- |
| Molecular Weight |
100871 |
| Protein Length |
902 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. |
| Function (UniProt annotation) |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Gene Ontology |
GO:0004970; GO:0004971; GO:0005231; GO:0005886; GO:0007215; GO:0030054; GO:0030666; GO:0032281; GO:0043025; GO:0043197; GO:0045211; GO:1903561 |
