| Gene |
NUMB
|
| Protein Name |
NUMB_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Protein numb homolog (h-Numb) (Protein S171) |
| Protein Family |
N/A |
| NCBI Gene ID |
8650
|
| UniProt ID |
P49757
|
| Enzyme Class |
- |
| Molecular Weight |
70804 |
| Protein Length |
651 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Membrane; Peripheral membrane protein. |
| Function (UniProt annotation) |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. |
| Gene Ontology |
GO:0005634; GO:0005769; GO:0005886; GO:0005925; GO:0007409; GO:0008013; GO:0016323; GO:0019897; GO:0021670; GO:0021849; GO:0030136; GO:0030335; GO:0034332; GO:0045177; GO:0045294; GO:0045296; GO:0050769; GO:0098978; GO:0099149; GO:1903077 |
