| Gene |
CLK3
|
| Protein Name |
CLK3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
1198
|
| UniProt ID |
P49761
|
| Enzyme Class |
2.7.12.1 |
| Molecular Weight |
73515 |
| Protein Length |
638 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Isoform 1: Nucleus. Cytoplasm; Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. |
| Function (UniProt annotation) |
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| Gene Ontology |
GO:0001669; GO:0003723; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0006468; GO:0016020; GO:0016607; GO:0042802; GO:0043484; GO:0045111; GO:0046777 |
