| Gene |
RANBP2
|
| Protein Name |
RBP2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) |
| Protein Family |
RanBP2 E3 ligase family |
| NCBI Gene ID |
5903
|
| UniProt ID |
P49792
|
| Enzyme Class |
2.3.2.- |
| Molecular Weight |
358199 |
| Protein Length |
3224 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). |
| Gene Ontology |
GO:0000413; GO:0001975; GO:0003723; GO:0005634; GO:0005635; GO:0005642; GO:0005643; GO:0005737; GO:0005739; GO:0005813; GO:0005829; GO:0006111; GO:0006406; GO:0006457; GO:0006607; GO:0008536; GO:0016020; GO:0016032; GO:0016925; GO:0019789; GO:0031965; GO:0033133; GO:0042405; GO:0043547; GO:0044614; GO:0044615; GO:0044877; GO:0046872; GO:0051642; GO:1990723 |
