| Gene |
Cdkn1c
|
| Protein Name |
CDN1C_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) |
| Protein Family |
CDI family |
| NCBI Gene ID |
12577
|
| UniProt ID |
P49919
|
| Enzyme Class |
- |
| Molecular Weight |
37372 |
| Protein Length |
348 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| Gene Ontology |
GO:0000122; GO:0001501; GO:0001822; GO:0001890; GO:0004861; GO:0005634; GO:0005737; GO:0007050; GO:0007096; GO:0007568; GO:0030099; GO:0030325; GO:0030511; GO:0035264; GO:0042326; GO:0042551; GO:0043010; GO:0044877; GO:0045893; GO:0050680; GO:0055123; GO:0060065; GO:0060669; GO:0071514; GO:1902746 |
