| Gene |
PDX1
|
| Protein Name |
PDX1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) |
| Protein Family |
Antp homeobox family |
| NCBI Gene ID |
3651
|
| UniProt ID |
P52945
|
| Enzyme Class |
- |
| Molecular Weight |
30771 |
| Protein Length |
283 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Cytoplasm, cytosol |
| Function (UniProt annotation) |
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| Gene Ontology |
GO:0000122; GO:0000978; GO:0000981; GO:0001889; GO:0003309; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005829; GO:0006006; GO:0006091; GO:0006366; GO:0007263; GO:0008284; GO:0008285; GO:0009887; GO:0016331; GO:0016607; GO:0030073; GO:0031017; GO:0031018; GO:0035774; GO:0042593; GO:0045944; GO:0048565; GO:0051594; GO:1902236; GO:2000675 |
