CaMKipedia | Result

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Sequence Viewer

Gene

PASK

Synonyms

KIAA0135

Protein Name

PAS domain-containing serine/threonine-protein kinase

UniProt ID

Q96RG2

Ensembl Gene ID

9606.ENSP00000234040

NCBI Gene ID

23178

Molecular Weight

1,42,929

Protein Length

1,323

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3dls)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Nucleus Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.

Function

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Gene Ontology

GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006468; GO:0035091; GO:0035556; GO:0043576; GO:0045719; GO:0045727; GO:0046777; GO:0070092; GO:0097009

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
GYS1 (P13834)	Oryctolagus cuniculus	S641	YRYPRPASVPPSPSL	-	0.7415	TP	certain	experimental	72 \| 73 \| 8 \| 55 \| 214 \|	16275910	-	In vitro
EEF1A1 (P68104)	Homo sapiens	T432	AVRDMRQTVAVGVIK	0.779	0.2364	TP	certain	experimental	66 \| 3 \| 214 \| 23 \| 62 \|	17595531	-	In vitro
PASK (Q96RG2)	Homo sapiens	T1161	ERGKLFYTFCGTIEY	0.673	0.0178	TP	certain	experimental	31 \| 94 \| 9 \|	11459942	-	-
PASK (Q96RG2)	Homo sapiens	T1165	LFYTFCGTIEYCAPE	0.644	0.0198	TP	certain	experimental	31 \| 94 \| 9 \|	11459942	-	-
Pdx1 (P52946)	Mus musculus	T152	EENKRTRTAYTRAQL	-	0.6712	TP	certain	experimental	72 \|	17052199	-	-
GYS1 (P13807)	Homo sapiens	S641	YRYPRPASVPPSPSL	0.951	0.712	-	-	-	-	-	-	-
RPS6 (P62753)	Homo sapiens	S235	IAKRRRLSSLRASTS	0.272	0.708	-	-	-	-	-	-	-
RPS6 (P62753)	Homo sapiens	S236	AKRRRLSSLRASTSK	0.934	0.6991	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1149	IKLIDFGSAAYLERG	0.353	0.0148	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1273	FRVNKPESGVLSAAS	0.686	0.384	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1277	KPESGVLSAASLEMG	0.506	0.5098	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1280	SGVLSAASLEMGNRS	0.606	0.5176	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1287	SLEMGNRSLSDVAQA	0.513	0.4582	-	-	-	-	-	-	-
PASK (Q96RG2)	Homo sapiens	S1289	EMGNRSLSDVAQAQE	0.746	0.4017	-	-	-	-	-	-	-
N/A (A8K6K7)	Homo sapiens	S641	YRYPRPASVPPSPSL	-	0.712	-	-	-	-	-	-	-
PDX1 (P52945)	Homo sapiens	T151	EENKRTRTAYTRAQL	0.871	0.6427	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found