| Gene |
ATXN1
|
| Protein Name |
ATX1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Ataxin-1 (Spinocerebellar ataxia type 1 protein) |
| Protein Family |
ATXN1 family |
| NCBI Gene ID |
6310
|
| UniProt ID |
P54253
|
| Enzyme Class |
- |
| Molecular Weight |
86923 |
| Protein Length |
815 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). |
| Gene Ontology |
GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006396; GO:0007420; GO:0007612; GO:0007613; GO:0008022; GO:0008266; GO:0016363; GO:0034046; GO:0035176; GO:0042405; GO:0042802; GO:0043621; GO:0045892; GO:0051168 |
